耿俊华，副研究员，硕士生导师
Email：gengjunhua@seu.edu.cn
办公地点：南京市浦口区东大路2号，汇川院A405
个人简介：
本科毕业于安徽农业大学（生物技术），硕士毕业于海洋之神之线路检测中心（遗传学），博士毕业于北京师范大学（细胞生物学），随后于美国南加州大学接受博士后训练。2018 年入职海洋之神之线路检测中心。
研究方向：突触结构与功能，及其与疾病的关联
神经元之间通过突触相互联结来传递信息。解析突触蛋白在突触中的组织架构、以及在神经活动过程中的动态特性，是解密大脑奥秘的一个关键环节。神经活动调节突触局部蛋白质合成、组装，诱导突触蛋白修饰，从而调控突触功能并使神经回路对外界刺激产生动态响应。我们主要运用遗传学，生物化学与分子生物学，细胞生物学和电子显微镜等方法与手段，通过对突触内蛋白质的修饰调控，蛋白质机器的组装，以及突触结构与功能的研究，揭示神经活动对突触发育和可塑性的调控机理，为神经可塑性相关疾病的预防和治疗提供理论依据。
主要代表性论文：
1. Gan Guangming*, Chen Mei, Yu Qinfeng, Gao Xiang, Zhang Chenchen, Sheng Qingyuan, Xie Wei, Geng Junhua*. Neurexin and neuroligins jointly regulate synaptic degeneration at the Drosophila neuromuscular junction based on TEM studies. Front Cell Neurosci,2023,17:1257347.2. Gan Guangming*; Chen Mei; Zhang Chenchen; Xie Wei; Geng Junhua*. Improved analysis method of neuromuscular junction in Drosophila larvae by transmission electron microscopy. Anat Sci Int, 2021, https://doi.org/10.1007/s12565-021-00635-6
3. Peng Yi-Jheng#; Geng Junhua#; Wu Ying; Pinales Cristian; Langen Jennifer; Chang Yen-Ching; Buser Christopher; Chang Karen T.*. Minibrain kinase and calcineurin coordinate activity-dependent bulk endocytosis through synaptojanin, J Cell Biol, 2021, 220 (12): e202011028. https://doi.org/10.1083/jcb.202011028
4. Gan Guangming*; Geng Junhua; Chen chen; Mou Yang; Xie Wei. Neurexin and Neuroligins maintain the balance of ghost boutons and satellite boutons at the Drosophila neuromuscular junction, Front. Neuroanat, 2020, 14:19. doi: 10.3389/fnana.2020.00019
5. Lee Joo Yeun; Geng Junhua; Lee Juhyun; Wang Andrew R.; Chang Karen T. *. Activity-Induced Synaptic Structural Modifications by an Activator of Integrin Signaling at the Drosophila Neuromuscular Junction. The Journal of Neuroscience, 2017, 37:3246-3263.
6. Geng Junhua#; Xia Lu#; Li Wanjie; Zhao Changqi; Dou Fei*. Cycloheximide Treatment Causes a ZVAD-Sensitive Protease-Dependent Cleavage of Human Tau in Drosophila Cells. Journal of Alzheimer's Disease, 2016, 49:1161-1168.
7. Geng Junhua#; Wang Liping#; Lee Joo Yeun; Chen Chun-Kan; Chang Karen T.*. Phosphorylation of Synaptojanin Differentially Regulates Endocytosis of Functionally Distinct Synaptic Vesicle Pools. The Journal of Neuroscience, 2016, 36:8882-8894.
8. Geng Junhua; Xia Lu; Li Wanjie; Dou Fei*. The C-terminus of tau protein plays an important role in its stability and toxicity. Journal of Molecular Neuroscience, 2015, 55:251-259.
发表文章完整列表：https://orcid.org/0000-0001-5817-8870
真诚欢迎各位志同道合的同学加入我们
